Revision Number:
N/A
Patient History and Background:
Case Study – 58 year old man with RCD. Duodenal Biopsy April 2014 – Abnormal cells seen on cytospin.
Interpretation:
41% of lymphoid cells show an aberrant intraepithelial T cell phenotype (cCD3+/sCD3neg/CD4neg/CD7pos/CD8neg/CD103pos).
Additional Tests :
Immunohistochemisty – CD3+intraepithelial lymphocytes increased. CD8+ cells less in number indicating loss of CD8. They do not express CD5 or CD2, rare cell CD4+.
Final Diagnosis:
RCD type II with mesenteric lymph node cavitation syndrome. No definite evidence of T cell lymphoma.
Supporting images:
Panel :
| Marker | Fluorochrome | Positive/ Negative |
|---|---|---|
| CD7 | FITC | Positive |
| CD4 | V450 | Negative |
| surface CD3 | PerCP-Cy5.5 | Negative |
| CD8 | APC-H7 | Negative |
| CD16/56 | PE-Cy7 | Negative |
| CD45 | V500 | Positive |
| cytoplasmic CD3 | APC | Positive |
| CD103 | FITC | Positve |
