Enteropathy-associated T-cell lymphoma & refractory coeliac disease

Authors: 
Janine Davies
Revision Number: 
N/A
Patient History and Background: 
Case Study – 58 year old man with RCD. Duodenal Biopsy April 2014 – Abnormal cells seen on cytospin.
Interpretation: 
41% of lymphoid cells show an aberrant intraepithelial T cell phenotype (cCD3+/sCD3neg/CD4neg/CD7pos/CD8neg/CD103pos).
Additional Tests : 
Immunohistochemisty – CD3+intraepithelial lymphocytes increased. CD8+ cells less in number indicating loss of CD8. They do not express CD5 or CD2, rare cell CD4+.
Final Diagnosis: 
RCD type II with mesenteric lymph node cavitation syndrome. No definite evidence of T cell lymphoma.
Supporting images: 
Panel : 
MarkerFluorochromePositive/ Negative
CD7FITCPositive
CD4V450Negative
surface CD3PerCP-Cy5.5Negative
CD8APC-H7Negative
CD16/56PE-Cy7Negative
CD45V500Positive
cytoplasmic CD3APCPositive
CD103FITCPositve

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